Policosanol is a mixture of aliphatic spirits obtained by hydrolyzing purified sugar cane wax.
Policosanol lowers LDL and total cholesterol by inhibiting cholesterol synthesis in the liver before mevalonate is formed. In addition, policosanol improves the binding, uptake and degradation of LDL cholesterol in the endoplasmic reticulum independently of its effect on cholesterol synthesis.

Castaño G, et al. Effects of policosanol on older patients with hypertension and type II hypercholesterolaemia. Drugs R D. 2002;3(3):159-72.

Olive leaf extract contains polyphenols, The most potent of which is hydroxytyrosol. It is a naturally active compound with antioxidant effects that supports cardiovascular health. The mechanism of action includes strong antioxidant and anti-inflammatory effects. The European Food Safety Authority (EFSA) has emphasized the importance of hydroxytyrosol in the protection of low-density lipoproteins and thus its effect on reducing the risk of cardiovascular disease, concluding that a daily intake of 5 mg of hydroxytyrosol and its derivatives is necessary to achieve this effect.

A causal relationship has been established between the consumption of olive oil polyphenols (standardized by the content of hydroxytyrosol and its derivatives) and the protection of LDL particles from oxidative damage. EFSA Journal 2011; 9(4):2033

Choline supports lipid metabolism and also reduces fat in the liver. Choline is necessary for the transport of lipids from the liver. It improves liver health and promotes lipid metabolism. Choline reduces fat in the liver. Choline is needed for cholesterol to be able to transport. Very low-density lipoprotein (VLDL) particles also transport triglycerides to tissues. As body cells extract fatty acids from VLDL, the particles are converted to medium-density lipoproteins and further to LDL particles.

Shaw GM, Finnell RH, Blom HJ, et al. Choline and risk of neural tube defects in a folate-fortified population. Epidemiology 2009;20(5):714-719

The active ingredient in turmeric extract is curcumin. It has antioxidant, anti-inflammatory and immune-stimulating properties. Turmeric extract stimulates bile secretion and helps protect the liver from the effects of harmful substances. Turmeric extract helps to maintain normal blood cholesterol levels, the functioning of the cardiovascular system, as well as to normalize liver lipids.

Niacin or vitamin B3 is important for normal cardiovascular health. It helps regulate blood pressure, blood lipids, and inflammation. Niacin improves the action of Monacolin K and inhibits the synthesis of triglycerides in the liver, as it directly affects one of the main enzymes of triglyceride synthesis – diacylglycerol acyltransferase (DGAT).

Vitamin B12 is a vital micronutrient for maintaining optimal hematopoietic, neurocognitive and cardiovascular function. It is involved in biochemical processes such as DNA synthesis, blood cell formation, maintenance of neurological functions and synthesis of neurotransmitters (dopamine, serotonin). B12 helps ensure normal homocysteine metabolism and also helps ensure normal energy-yielding metabolism.

Olive leaf extract contains polyphenols, the most potent of which is hydroxytyrosol. It is a naturally active compound with antioxidant effects that supports cardiovascular health. The mechanism of action includes strong antioxidant and anti-inflammatory effects. The European Food Safety Authority (EFSA) has emphasized the importance of hydroxytyrosol in the protection of low-density lipoproteins and thus its effect on reducing the risk of cardiovascular disease, concluding that a daily intake of 5 mg of hydroxytyrosol and its derivatives is necessary to achieve this effect. EFSA Journal 2011; 9(4):2033

Magnesium is the fourth most abundant mineral in the human body. It is involved in countless biochemical reactions and enzyme systems, and supports processes such as protein synthesis, cell growth, and energy production. Magnesium is needed for nerve function, muscle control, blood pressure regulation and glucose maintenance.

Potassium plays a role in every heartbeat. Potassium plays an important role in regulating the contractions of all muscles, including the heart muscle. Very low levels of potassium in the body can cause irregular heart rhythms, including sinus bradycardia, ventricular tachycardia, and ventricular fibrillation. People with low potassium intake are at increased risk of developing high blood pressure, especially if their diet is high in salt (sodium). Increasing the amount of potassium in your diet and reducing your sodium intake can help lower blood pressure and reduce the risk of stroke.

Vitamin B6 is important for various biological reactions of the body, such as the synthesis of neurotransmitters (serotonin, dopamine, histamine), amino acid metabolism and hemoglobin formation. Vitamin B6 contributes to the normal formation of red blood cells. Vitamin B6 and Magnesium help reduce fatigue and weakness. 

B vitamins, especially vitamin B1, are important for normal heart function. Normal heart function is beneficial for human health. EFSA has issued an opinion and statement that a causal relationship between dietary thiamine intake and cardiac function is established. This wording reflects the scientific evidence: Thiamine contributes to normal heart function.

Psyllium is soluble fiber that is the mucilaginous seed husk of the Plantago ovata plant. Psyllium helps to lower cholesterol when used together with a diet low in cholesterol and saturated fat. Psyllium absorbs water and become a thick, viscous compound that resists digestion in the small intestine. Resistance allows to help regulate high cholesterol, triglycerides, and blood sugar levels, also aid weight management and relieve mild diarrhea as well as constipation [1].