WHAT IS ATHEROSCLEROSIS?

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One of the most common causes of atherosclerosis is high cholesterol. Cholesterol, along with other substances, builds up in the blood vessels and causes a blockage called atherosclerosis. It interferes with blood flow and reduces the amount of oxygen and other nutrients in the body.

The development of atherosclerosis is influenced by age, genes and lifestyle.

WHAT ARE THE CONSEQUENCES OF ATHEROSCLEROSIS?

Atherosclerosis can affect the arteries in the heart, brain, arms, legs or kidneys, causing:

Heart attack, infarct

Angina (pain in the heart)

Stroke

Carotid artery damage (headache, dizziness)

Chronic kidney disease

77% of chemical statin users stops treatment in the first 2 years due to side effects

AteroLip® - first choice products for cholesterol lowering

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AteroLip®

Reduces total
cholesterol and LDL

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AteroLip® 5D

Reduces total cholesterol and LD, controls blood glucose level

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AteroLip® Fiber

Improves cholesterol
and blood glucose levels

AteroLip® - proven natural statin to lower cholesterol

All active substances in AteroLip are included in the 2019 European guidelines for dyslipidaemia

Red yeast rice (RYR) extract is a traditional Chinese medicine for cholesterol lowering. It also been used as a food coloring, additive, and preservative [1]. RYR contains more than 10 different monocolins from most effective for cholesterol lowering is Monacolin K. RYR is an effective and safe agent for improving lipid profile. RYR has been demonstrated to not only improve lipid metabolism, but it can also reduce blood pressure, and may possess anti-inflammatory, antidiabetic, anticancer, and osteogenic properties [2].

European Food Safety Authority investigated and confirmed a beneficial effect of Monacolin K on lipid spectrum [3].

1. Chen H-HS. Clinical inquiry: is red-yeast rice a safe and effective alternative to statins? J Fam Pract 2015; 64:128–135
2. Veronique Verhoeven. Red yeast rice lowers cholesterol in physicians – a double blind, placebo controlled randomized trial. BMC Complement Altern Med. 2013; 13: 178.
3. Patel S. Functional food red yeast rice (RYR) for metabolic syndrome amelioration: a review on pros and cons. World J. Microb. Biot. (2016) 32:2035–2042.

Berberine is an active ingredient with cholesterol lowering properties, that is extracted from plants of the genus Berberis. Berberine helps to lower LDL cholesterol and triglyceride levels. Besides reduction of cholesterol, berberine is also used to lower blood pressure and increase weight/fat reduction [1].

1.Dong H. The effects of berberine on blood lipids: a systemic review and meta-analysis of randomized controlled trials. Planta Med. 2013 Apr;79(6):437-46.

Flavonoids are one of the basic units in the Mediterranean diet, which helps to improve fat metabolism and strengthen blood vessel walls [1]. Blueberries cause positive changes in human health indicators, such as decreasing low-density lipoprotein cholesterol and triglycerides and increasing high-density lipoprotein cholesterol [2].

1.Akhlaq A. F., Tahira F. Chapter 27 – Importance of Fruit and Vegetable-Derived Flavonoids in the Mediterranean Diet: Molecular and Pathological Aspects, Role of the Mediterranean Diet in the Brain and Neurodegenerative Diseases, Academic Press, 2018 p. 417-427.
2.Marta Habanova. Intake of bilberries (Vaccinium myrtillus L.) reduced risk factors for cardiovascular disease by inducing favorable changes in lipoprotein profiles. Nutr Res. 2016 Dec;36(12):1415-1422.

AteroLip, like chemical statins, inhibits HMG-Coa carboxylase

Usage

AteroLip® 5D - for diabetic patients with high cholesterol

Cinnamon is a spice that is made from the inner bark of trees. Cinnamon has a wide biochemical composition, including minerals (iron, calcium), polyphenols (cinnamon aldehyde, cinnamic acid) and other antioxidants. Due to its wide range, cinnamon is recommended for use in diabetes, arthritis, atherosclerosis, cardiovascular and neurological pathologies [1].

1.Hariri M., Ghiasvand R. Cinnamon and chronic diseases. Adv Exp Med Biol. 2016, 929, pp. 1-24.

Red yeast rice (RYR) extract is a traditional Chinese medicine for cholesterol lowering. It also been used as a food coloring, additive, and preservative [1]. RYR contains more than 10 different monocolins from most effective for cholesterol lowering is Monacolin K. RYR is an effective and safe agent for improving lipid profile. RYR has been demonstrated to not only improve lipid metabolism, but it can also reduce blood pressure, and may possess anti-inflammatory, antidiabetic, anticancer, and osteogenic properties [2].

European Food Safety Authority investigated and confirmed a beneficial effect of Monacolin K on lipid spectrum [3].

1.Chen H-HS. Clinical inquiry: is red-yeast rice a safe and effective alternative to statins? J Fam Pract 2015; 64:128–135
2.Veronique Verhoeven. Red yeast rice lowers cholesterol in physicians – a double blind, placebo controlled randomized trial. BMC Complement Altern Med. 2013; 13: 178.
3.Patel S. Functional food red yeast rice (RYR) for metabolic syndrome amelioration: a review on pros and cons. World J. Microb. Biot. (2016) 32:2035–2042.

Magnesium is the fourth most common mineral in the human body. It is involved in countless biochemical reactions and enzyme systems, as well as supporting processes such as protein synthesis, cell growth and energy production. Magnesium is needed for nerve function, muscle control, blood pressure regulation and glucose maintenance [1].

Among diabetic patients maintenance of magnesium levels is often neglected , although magnesium deficiency are increasingly common in type 2 diabetes. Oral magnesium is recommended for patients with type 2 diabetes to reduce magnesium deficiency, insulin resistance, oxidative stress levels, and systemic inflammation [2].

1.Romani A. Chapter 3. Magnesium in Health and Disease. Metal Ions in Life Sciences. 2013, 13. Springer. pp. 49–79.
2.Barbagallo M., Dominguex L.J. Magnesium and type 2 diabetes. World J Diabetes. Aug 2015, 6(10), pp. 1152-1157.

Chromium is a vital mineral for the functioning of the body. Not only does it maintain normal insulin and serum glucose levels [1], but it also acts as a cofactor for the synthesis of various amino acids such as glycine, cysteine, glutamic acid, and aspartic acid [2]. Insulin resistance is observed in various cases of metabolic syndrome, such as type 2 diabetes, obesity, and hypertension [3].

1.Ryan B. Chromium in diabetes: the controversy continues. Diabetes Action. Oct 2006.
2.Cefalu W.T., Hu F.B. Role of chromium in human health and in diabetes. Diabetes Care. Nov 2004, 27(11), pp. 2741-2751.
3.Tsave O., Yavropoulou M.P., Kafantari M., et al. The adipogenic potential of Cr (III). A molecular approach exemplifying metal-induced enhancement of insulin mimesis in diabetes mellitus II. J Inorg Biochem. Jul 2016.

Vitamin D3 is a fat-soluble vitamin that acts as a hormone-type antioxidant and is required for the functioning of all cells in the body [1]. The main functions include the provision of calcium homeostasis and bone mass, as well as antibacterial, antioxidant, immunomodulatory and anti-inflammatory properties [2].

Insulin sensitivity has been shown to be regulated by both vitamin D and adiponectin (a protein that regulates serum glucose in humans) [3].

1.Rader C.P., Corsten N., Rolf O. Osteomalacia and vitamin D deficiency. Orthopade. Sep 2015, 44 (9), pp. 695-702
2.Vojinovic J., Cimaz R. Vitamin D – update for the pedriatric rheumatologists. Pedriatr Theumatol Online J. May 2015, 29 (13), pp. 18.
3.Westra S., Krul-Poel Y.H., van Wijland H., et al. Effect of vitamin D supplementation on health status in non-vitamin D deficient people with type 2 diabetes mellitus. Endocr Connect. Nov 2016.

Vitamin B12 is a vital trace element for maintaining optimal hematopoietic, neurocognitive and cardiovascular function. It is involved in biochemical processes such as DNA synthesis, blood cell formation, maintenance of neurological functions and synthesis of neutotransmitters (dopamine, serotonin). Vitamin B12 deficiency is common in patients with type 1 and type 2 diabetes [1].

1.Kibirige D., Mwebaze R. Vitamin B12 deficiency among patients with diabetes mellitus: is routine screening and supplementation justified? Journal of Diabetes & Metabolic Disorders. 2013, 12, pp. 17

Vitamin B6 is one of the B group vitamins.Vitamin B6 is important for various biological reactions in organism  such as the synthesis of neurotransmitters (serotonin, dopamine, histamine), amino acid metabolism, and hemoglobin formation. Vitamin B6 deficiency is often associated with stress, anxiety and metabolism leading to various cardiovascular and metabolic dysfunctions. Chronic stress and inflammation are among the leading factors contributing to the development of type 2 diabetes in patients with pre-diabetic predisposition [1].

1.Almeida M.R., Mabasa L., Crane C., et al. Maternal vitamin B6 deficient or supplemented diets on expression of genes related to GABAergic, serotonergic, or glutamatergic pathways in hippocampus of rat dams and their offspring. Mol Nutr Food Res. Jul 2016, 60(7), pp. 1615-1624.

When to choose AteroLip® 5D?

Usage

AteroLip® Fiber - the most effective non-statin therapy for lowering cholesterol

FDA and Efsa approved Beta-glucan for lowering cholesterol and blood glucose level

Beta-glucan is one form of soluble dietary fiber that’s strongly linked to improving cholesterol levels and boosting heart health [1].

There’s solid evidence that beta glucan can boost heart health. The U.S. Food and Drug Administration (FDA) has approved a heart-healthy label for foods that have high amounts of beta glucan, based on this evidence. Several studies suggest that beta glucan may lower cholesterol and triglycerides. Eating at least 3 g of beta glucan daily reduced bad cholesterol (LDL) levels. Beta glucans also helps to reduce the risk of type 2 diabetes by improving blood sugar level [2].

Researchers think that beta glucan could also have some positive effects on the immune system [3].

1.Othman RA, Moghadasian MH, Jones PJ. Cholesterol-lowering effects of oat β-glucan. Nutr Rev. 2011;69(6):299-309.
2.Jenkins DJ, Kendall CW, Vuksan V, et al. Soluble fiber intake at a dose approved by the US Food and Drug Administration for a claim of health benefits: serum lipid risk factors for cardiovascular disease assessed in a randomized controlled crossover trial. Am J Clin Nutr. 2002;75(5):834-839.
3.Sima P, Vannucci L, Vetvicka V. β-glucans and cholesterol (Review). Int J Mol Med. 2018;41(4):1799-1808.

Psyllium is soluble fiber that is the mucilaginous seed husk of the Plantago ovata plant. Psyllium helps to lower cholesterol when used together with a diet low in cholesterol and saturated fat. Psyllium absorbs water and become a thick, viscous compound that resists digestion in the small intestine. Resistance allows to help regulate high cholesterol, triglycerides, and blood sugar levels, also aid weight management and relieve mild diarrhea as well as constipation [1].

Fibers form a viscous net which captures cholesterol related particles so they are not absorbed in bloodstream

Usage

Efficacy has been proved in general practitioners' observations in Latvia from 2016 to 2019

Total cholesterol reduction after administration of AteroLip®

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LDL reduction after administration of AteroLip®

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"Natural statins were used in the Chinese population even B.C. Watch the video to find out how the natural statin product AteroLip® was formed."

FREQUENTLY ASKED QUESTIONS

As with chemical statins, AteroLip® should be taken once daily at bedtime to achieve a peak of AteroLip® concentrations during the peak of endogenous cholesterol synthesis.

After consulting your doctor, you can stop taking AteroLip®, but you need to monitor your cholesterol levels and take it twice a year for 3 months.

Yes you can, but before that we recommend consulting your doctor.

AteroLip® is suitable for all patients with high cholesterol level and high risk of atherosclerosis. AteroLip 5D is based on the recommendations of endocrinologists and cardiologists to ensure the highest quality of life for diabetic patients.

AteroLip® Fiber is the safest and most promising non-statin therapy product which helps to improve cholesterol and glucose levels.

ABOUT US

Lotos Pharma is a fast growing Latvian pharmaceutical manufacturer, founded in 2013 💊. The company works purposefully and carefully following the wishes of consumers in order to offer innovative and easy-to-use pharmaceutical products that meet modern quality requirements and are developed on the basis of the latest research. The range of products includes food supplements, medical devices, cosmetics and other health preparations, which are developed in cooperation with doctors, pharmacists and scientific institutions to meet the highest requirements and would be safe for use by everyone – both the youngest and the elderly.
You are welcome to take a look at our manufacture!👩‍🔬👨‍⚕️ #lotospharma#madeineurope #health 🌿

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